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Curtain Raiser 25 – Fertility Preservation & Art

Fertility preservation and Assisted Reproductive Technologies (ART) play a vital role in safeguarding fertility for individuals undergoing medical treatments or facing other fertility-threatening circumstances.

In this video, we explore various fertility preservation techniques, including oocyte freezing, ovarian transplants, and sperm freezing, to help you make informed decisions about preserving your fertility.

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Introduction to Fertility Preservation & ART

Oocyte Freezing: A promising option for Women

• The process of oocyte freezing

  • Ovarian stimulation
  • Egg retrieval procedure
  • Denuding and assessment
  • Cryoprotectant addition
  • Vitrification technique
  • Long-term storage

• Ideal candidates for oocyte freezing

  • Cancer patients pre-treatment
  • Delaying childbearing
  • Diminished ovarian reserve
  • Family history of early menopause
  • Ethical concerns with embryos
  • Cancer and Fertility Preservation

• The impact of cancer treatments on fertility

  • Chemotherapy: potential damage to eggs or sperm, may cause premature menopause
  • Radiation: potential harm to reproductive organs, may affect hormone production
  • Surgery: removal of reproductive organs, may impact fertility directly

• Fertility preservation options for cancer patients

  • Oocyte freezing: preserving a woman’s eggs before treatment
  • Sperm freezing: preserving a man’s sperm before treatment
  • Embryo freezing: creating and preserving embryos for future use
  • Ovarian tissue cryopreservation (OTC): preserving ovarian tissue containing immature
  • Ovary transposition: surgically moving the ovaries away from the radiation field
  • Gonadotropin-releasing hormone (GnRH) agonists: medication to temporarily suppress ovarian function during treatment
Breast Cancer and Fertility Preservation

• Addressing fertility concerns in breast cancer patients

  • Early fertility consultation
  • Assess the patient’s fertility
  • Evaluate treatment impact
  • Personalized preservation plan

• Fertility preservation methods for breast cancer patients

  • Embryo freezing
  • Egg freezing
  • Ovarian tissue cryopreservation
  • Ovary transposition
  • GnRH agonist therapy
Ovarian Transplant and Ovary Transposition

• How these procedures work

  • Ovarian transplant: Cryopreserved tissue reimplanted
  • Ovary transposition: Ovaries repositioned surgically

• Benefits and potential risks

  • Fertility restoration
  • Natural hormone production
  • Reduces premature menopause
  • Surgical complications possible
  • Transplant rejection risk
Sperm Freezing: Preserving male fertility
• The sperm-freezing process
  • Semen collection
  • Semen analysis
  • Cryoprotectant addition
  • Controlled-rate freezing
  • Long-term storage

• Factors affecting sperm viability post-thaw

  • Pre-freeze sperm quality
  • Cryoprotectant type
  • Freezing/thawing protocols
  • Storage duration
  • Individual variability
Ovarian Tissue Cryopreservation (OTC)

• The role of OTC in fertility preservation

  • Protects fertility by freezing ovarian tissue before medical treatments that may cause infertility.
  • Important for prepubertal girls and young women who cannot undergo other fertility preservation
  • OTC enables women to postpone childbearing by preserving their fertility potential.
  • Ovarian tissue can be transplanted back after medical treatments to restore fertility.
  • OTC can be used as a source of natural hormones for premature ovarian failure

• Advancements in OTC techniques

  • Vitrification
  • Vitro maturation
  • Robotic-assisted transplantation
  • Tissue engineering
  • Biomaterial