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CURTAIN RAISER 8 – Gonadotrophin in Assisted Reproductive Technology (ART)

This video will give an in-depth overview of understanding the Role of Gonadotrophins in Infertility and ART

Follicle Stimulating Hormone (FSH)

  • Essential for follicle growth and maturation
  • Regulates the production of Estradiol in women and sperm production in men
  • Luteinizing Hormone (LH)
  • Triggers ovulation in women
  • Supports testosterone production in men
  • Estradiol
  • Key hormone for female reproductive health
  • Regulates menstrual cycle and supports embryo implantation
  • Serum Progesterone
  • Supports the endometrium to allow embryo implantation
  • Indicates the presence of a functional corpus luteum
  • Assessing Ovarian Reserve and Hormonal Therapy Options

    Ovarian Reserve
  • Evaluates a woman’s reproductive potential
  • Involves assessing the number of available eggs and their quality
  • Clomiphene and Letrozole
  • Oral medications used to stimulate ovulation
  • Induce the release of gonadotrophins (FSH and LH) from the pituitary gland
  • Gonadotrophin Therapy

    a.Injection-based hormonal treatment

    It involves injecting synthetic hormones into a woman’s body to stimulate the ovaries to produce eggs. These hormones mimic the action of the natural hormones produced by the pituitary gland in the brain that regulate the menstrual cycle.

    b.Directly stimulates the ovaries

    The hormones in the injections stimulate the follicles in the ovaries to grow and mature. Follicles are fluid-filled sacs that contain immature eggs. The therapy aims to stimulate the ovaries to produce multiple mature follicles.

    c.Produce multiple mature follicles

    The goal of gonadotrophin therapy is to produce multiple mature follicles that can be fertilized by sperm. This increases the chances of pregnancy for women who are having difficulty conceiving. The maturation of multiple follicles is monitored through ultrasound scans and blood tests, and the timing of ovulation is determined to optimize the chances of fertilization.

    Types of Gonadotrophins Used in ART

    Human Menopausal Gonadotrophins (HMG)
  • Obtained from the urine of postmenopausal women
  • Contains a mix of FSH and LH
  • Human Chorionic Gonadotrophin (HCG)
  • Mimics the action of LH
  • Used to trigger ovulation in ART
  • Recombinant Gonadotrophins
  • Produced using recombinant DNA technology
  • Offers greater purity and consistency
  • Commonly Used Recombinant Gonadotrophins

    Gonal-f (Recombinant FSH)
  • Used to stimulate follicle development in women
  • Can also be used for male fertility treatment
  • Recagon (Recombinant FSH)
  • Similar to Gonal-f in function
  • Another option for follicle stimulation in women
  • Follisurge (Recombinant LH)
  • Supports follicle maturation and ovulation
  • Often used in combination with recombinant FSH
  • Folligraph (Recombinant HCG)
  • Triggers final oocyte maturation and ovulation
  • Used in ART procedures like in vitro fertilization (IVF) and intrauterine insemination (IUI)
  • Urinary Gonadotrophins
  • Alternative to recombinant gonadotrophins
  • Derived from human urine
  • May contain varying levels of FSH, LH, and HCG